Synthesis, screening and QSAR studies of 2,4-disubstituted 1,5-benzodiazepine derivatives
نویسندگان
چکیده
New 2,4-disubstituted 1,5-benzodiazepine derivatives containing different functional groups have been synthesized and screened for their antibacterial activity. The 2,4-disubstituted 1,5benzodiazepine derivatives were synthesized by reacting substituted chalcones synthesized using aldol condensation with o-phenylenediamine. QSAR studies of synthesized derivatives were performed. QSAR equation show that electronic and liphopholic parameters have good correlation with anti bacterial activity. Lead molecules, which are designed in accordance with QSAR equations, are exhibit improved antibacterial activity.
منابع مشابه
Synthesis and Anti-inflammatory Activity of Some Novel 1,5 Benzodiazepine Derivatives
Objective: The objective of the study is to synthesize some novel 1,5-benzodiazepine derivatives from chalcones. The structures of the newly synthesized compounds were characterized by elemental analysis, infrared, 1H nuclear magnetic resonance, and mass spectroscopic studies. All titled compounds were screened for their anti-inflammatory activity. Methods: In this study, a series of novel 2-(s...
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